Aside from the tragic assassinations of John F. Kennedy in 1963 and his brother Bobby Kennedy in 1968, their brother Ted Kennedy ran his car off a bridge in Chappaquiddick in 1969, and managed to escape - but his passenger, Mary Jo Kopechne, was not so lucky - she drowned, leading to conspiracy theories that Kennedy had driven the car into the water on purpose. In 1999, JFK's son died in a plane crash with his wife and her sister.